Depression, antidepressants, and the shrinking hippocampus

    These findings of hippocampal atrophy raise immediate questions. First, is it per-manent? Tentatively, this appears to be the case, as the atrophy persisted for up to decades after the depressions were in re-mission. In addition, the extent of atrophy did not lessen with increasing duration of remission (2–4). Next, does the hippocampal atrophy

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